HCID 59323414, compound → HCID 59323083, compound

Participants

Reaction Steps

N-(benzyloxycarbonyl)-N-[3,5-bis(methanesulfonyl)aminobenzyl]-2-[6-fluoro-3-(4-fluorobenzyl)-3,4-dihydroisoquinolin-2(1H)-yl]ethanamine (25.0 mg, 0.04 mmol) was dissolved in 1.5 mL of methanol, and 100 mg of Pd—C was added thereto at room temperature, followed by stirring for 1.5 hours under a hydrogen gas atmosphere. After completion of the reaction, the reaction liquid was filtered through Celite. The filtrate was concentrated under reduced pressure, and the solvent was removed by evaporation and purified by PLC to obtain 6.8 mg (yield 33%) of a desired product as a pale yellow oily substance.

Provenance & Evidence