Hydrochloric Acid → HCID 59323077, compound

Participants

Reaction Steps

4-[[2-[6-fluoro-3-(4-fluorobenzyl)-3,4-dihydroisoquinolin-2(1H)-yl]ethylamino]methyl]-N-ethoxycarbonylaniline (10 mg, 0.02 mmol) obtained in Example 142 and lithium hydroxide.monohydrate (41 mg, 1.0 mmol) were dissolved in 1 mL of THF and 0.5 mL of water, followed by stirring at room temperature overnight. After completion of the reaction, 2N hydrochloric acid was added to the reaction liquid, followed by extraction with chloroform. The organic layer was then washed with saturated brine, dried over anhydrous sodium sulfate and then concentrated under reduced pressure to obtain 3 mg (yield 44.2%) of a title compound as a pale yellow oily substance.

Provenance & Evidence