HCID 20566241, compound → HCID 25158199, compound

HRID 2390069Notes

Reaction equation

HRID 2390069 reaction equation
[Cl:1][C:2]1[CH:19]=[CH:18][C:5]([CH2:6][CH:7]2[CH2:16][C:15]3[C:10](=[CH:11][CH:12]=[C:13]([F:17])[CH:14]=3)[CH2:9][NH:8]2)=[CH:4][CH:3]=1.C([CH:27]1[CH2:36][C:35]2[C:30](=[CH:31][CH:32]=[CH:33][CH:34]=2)[CH2:29][NH:28]1)C1C=CC=CC=1>>[C:5]([C:33]1[CH:32]=[CH:31][C:30]([CH2:29][NH:28][CH2:27][CH2:36][N:8]2[CH:7]([CH2:6][C:5]3[CH:18]=[CH:19][C:2]([Cl:1])=[CH:3][CH:4]=3)[CH2:16][C:15]3[C:10](=[CH:11][CH:12]=[C:13]([F:17])[CH:14]=3)[CH2:9]2)=[CH:35][CH:34]=1)([CH3:18])([CH3:6])[CH3:4]

Participants

3

Reactant 2

HCID 20566241HCID 20566241, compoundHCID 59323210HCID 59323210, compound

Product 1

HCID 25158199HCID 25158199, compound

Procedure

The reaction and treatment were carried out in the same manner as in Example 78 using 3-(4-chlorobenzyl)-6-fluoro-1,2,3,4-tetrahydroisoquinoline obtained in Example 55-a) instead of 3-benzyl-1,2,3,4-tetrahydroisoquinoline to obtain a title compound as a light yellow oily substance.

Workup

  1. customThe reaction and treatment

Sources & evidence

ORD record
ord-82a111182c234025bf74ce2042b5db95
Source dataset
uspto-grants-2012_09
Patent number
US08273766B2

Reaction notes

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