HCID 59323213, compound → HCID 59323278, compound

HRID 2390070Notes

Reaction equation

HRID 2390070 reaction equation
[F:1][C:2]1[CH:11]=[C:10]2[C:5]([CH2:6][CH:7]([CH2:12][C:13]3[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=3)[NH:8][CH2:9]2)=[CH:4][CH:3]=1.[C:20]([O:24][C:25]([N:27]([CH2:38][CH:39]=O)[CH2:28][C:29]1[CH:34]=[CH:33][C:32]([N+:35]([O-:37])=[O:36])=[CH:31][CH:30]=1)=[O:26])([CH3:23])([CH3:22])[CH3:21]>>[N+:35]([C:32]1[CH:31]=[CH:30][C:29]([CH2:28][N:27]([CH2:38][CH2:39][N:8]2[CH:7]([CH2:12][C:13]3[CH:14]=[CH:15][C:16]([F:19])=[CH:17][CH:18]=3)[CH2:6][C:5]3[C:10](=[CH:11][C:2]([F:1])=[CH:3][CH:4]=3)[CH2:9]2)[C:25](=[O:26])[O:24][C:20]([CH3:23])([CH3:22])[CH3:21])=[CH:34][CH:33]=1)([O-:37])=[O:36]

Participants

3

Reactant 2

HCID 59323213HCID 59323213, compoundHCID 59323416HCID 59323416, compound

Product 1

HCID 59323278HCID 59323278, compound

Procedure

The reaction and treatment were carried out in the same manner as in Example 117-d) using 7-fluoro-3-(4-fluorobenzyl)-1,2,3,4-tetrahydroisoquinoline obtained in Example 56-c) and [N-(tert-butoxycarbonyl)-N-4-nitrobenzylamino]acetaldehyde to obtain a title compound as a light yellow oily substance.

Workup

  1. customThe reaction and treatment

Sources & evidence

ORD record
ord-7a9a554ad378472caadce509e2af13e6
Source dataset
uspto-grants-2012_09
Patent number
US08273766B2

Reaction notes

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