HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2390074Generated: October 31, 2026
Potassium Carbonate → N-(2-ethylpyridin-4-yl)methyl-2-[6-fluoro-3-(4-fluorobenzyl)-3,4-dihydroisoquinolin-2(1H)-yl]ethanamine
https://huagongshe.com/reaction/2390074
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-[6-fluoro-3-(4-fluorobenzyl)-3,4-dihydroisoquinolin-2(1H)-yl]ethanamine | HCID 59323071 | — |
| Reactant | HCID 59323470 | HCID 59323470 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | N-(2-ethylpyridin-4-yl)methyl-2-[6-fluoro-3-(4-fluorobenzyl)-3,4-dihydroisoquinolin-2(1H)-yl]ethanamine | HCID 59323184 | 28.3% |
Reaction Steps
67 mg of 2-[6-fluoro-3-(4-fluorobenzyl)-3,4-dihydroisoquinolin-2(1H)-yl]ethanamine obtained in Example 180-b), 47 mg of 2-ethyl-4-[(methyl sulfonyl oxy)methyl]pyridine, and 30 mg of potassium carbonate were added to acetonitrile (2 ml), followed by stirring at 60° C. for 2 hours. After concentration, it was purified by PLC (chloroform:methanol=10:1) to obtain 26 mg (yield 28%) of a title compound as a yellow oily substance.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08273766B2 |
|---|
| Source dataset | uspto-grants-2012_09 |
|---|
| ORD ID | ord-f3056ebcf6f7444cb44a7c3ca9982050 |
|---|
| Source note | uspto-grants-2012_09 |
|---|
