3-Isocyanatobenzonitrile → HCID 59323319, compound

HRID 2390077Notes

Reaction equation

HRID 2390077 reaction equation
[F:1][C:2]1[CH:21]=[CH:20][C:5]([CH2:6][CH:7]2[CH2:16][C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[CH2:9][N:8]2[CH2:17][CH2:18][NH2:19])=[CH:4][CH:3]=1.[C:22]([C:24]1[CH:25]=[C:26]([N:30]=[C:31]=[O:32])[CH:27]=[CH:28][CH:29]=1)#[N:23]>>[C:22]([C:24]1[CH:25]=[C:26]([NH:30][C:31]([NH:19][CH2:18][CH2:17][N:8]2[CH:7]([CH2:6][C:5]3[CH:20]=[CH:21][C:2]([F:1])=[CH:3][CH:4]=3)[CH2:16][C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[CH2:9]2)=[O:32])[CH:27]=[CH:28][CH:29]=1)#[N:23]

Participants

3

Reactant 2

HCID 27333153-IsocyanatobenzonitrileHCID 59323164HCID 59323164, compound

Product 1

HCID 59323319HCID 59323319, compound

Procedure

The reaction and treatment were carried out in the same manner as in Example 208 using 2-[3-(4-fluorobenzyl)-3,4-dihydroisoquinolin-2(1H)-yl]ethanamine obtained in Example 210-a) as a starting material, and using 3-cyanophenyl isocyanate instead of phenyl isocyanate to obtain a title compound as a pale yellow amorphous substance.

Workup

  1. customThe reaction and treatment

Sources & evidence

ORD record
ord-0ef925195723432b849cccc4ea7a8887
Source dataset
uspto-grants-2012_09
Patent number
US08273766B2

Reaction notes

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