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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2390080Generated: October 25, 2026

2-Ethylphenyl isocyanate → 1-(2-ethyl phenyl)-3-[3-[3-(4-fluorobenzyl)-3,4-dihydroisoquinolin-2(1H)-yl]propyl]urea

https://huagongshe.com/reaction/2390080

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Ethylphenyl isocyanateHCID 583486—
Reactant3-[3-(4-fluorobenzyl)-3,4-dihydroisoquinolin-2(1H)-yl]propanamineHCID 59323365—
Product1-(2-ethyl phenyl)-3-[3-[3-(4-fluorobenzyl)-3,4-dihydroisoquinolin-2(1H)-yl]propyl]ureaHCID 59323469—

Reaction Steps

The reaction and treatment were carried out in the same manner as in Example 208 using 3-[3-(4-fluorobenzyl)-3,4-dihydroisoquinolin-2(1H)-yl]propanamine obtained in Example 214-b) as a starting material, and using 2-ethylphenyl isocyanate instead of phenyl isocyanate to obtain a title compound as a pale yellow amorphous substance.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08273766B2
Source datasetuspto-grants-2012_09
ORD IDord-30de7d96824b4606862abaac3e476962
Source noteuspto-grants-2012_09