Water → HCID 59323250, compound

Participants

Reaction Steps

30 mg of 3-[3-(4-fluorobenzyl)-3,4-dihydroisoquinolin-2(1H)-yl]propanamine obtained in Example 214-b), 28 mg of (3-dimethylaminophenyl)phenyl carbamate, and 31 mg of triethylamine were dissolved in 1 mL of toluene, followed by stirring under reflux for 30 minutes. After completion of the reaction, water was added to the reaction liquid, followed by extraction with ethyl acetate. The organic layer was then washed with saturated brine, dried over anhydrous sodium sulfate and then concentrated under reduced pressure. The residue obtained was purified using PLC (chloroform:methanol=10:1) to obtain 22.3 mg (yield 48%) of a title compound as a pale yellow oily substance.

Provenance & Evidence