3-Methoxyphenyl isocyanate → 1-[3-[6-fluoro-3-(4-fluorobenzyl)-3,4-dihydroisoquinolin-2(1H)-yl]propyl]-3-(3-methoxyphenyl)urea

HRID 2390098Notes

Reaction equation

HRID 2390098 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH2:8][N:7]([CH2:12][CH2:13][CH2:14][NH2:15])[CH:6]([CH2:16][C:17]1[CH:22]=[CH:21][C:20]([F:23])=[CH:19][CH:18]=1)[CH2:5]2.[CH3:24][O:25][C:26]1[CH:27]=[C:28]([N:32]=[C:33]=[O:34])[CH:29]=[CH:30][CH:31]=1>>[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH2:8][N:7]([CH2:12][CH2:13][CH2:14][NH:15][C:33]([NH:32][C:28]1[CH:29]=[CH:30][CH:31]=[C:26]([O:25][CH3:24])[CH:27]=1)=[O:34])[CH:6]([CH2:16][C:17]1[CH:18]=[CH:19][C:20]([F:23])=[CH:21][CH:22]=1)[CH2:5]2

Participants

3

Reactant 2

HCID 878433-Methoxyphenyl isocyanateHCID 593232933-[6-fluoro-3-(4-fluorobenzyl)-3,4-dihydroisoquinolin-2(1H)-yl]propanamine

Product 1

HCID 593232191-[3-[6-fluoro-3-(4-fluorobenzyl)-3,4-dihydroisoquinolin-2(1H)-yl]propyl]-3-(3-methoxyphenyl)urea

Procedure

The reaction and treatment were carried out in the same manner as in Example 208 using 3-[6-fluoro-3-(4-fluorobenzyl)-3,4-dihydroisoquinolin-2(1H)-yl]propanamine obtained in Example 238-b) as a starting material, and using 3-methoxyphenyl isocyanate instead of phenyl isocyanate to obtain a title compound as a pale yellow amorphous substance.

Workup

  1. customThe reaction and treatment

Sources & evidence

ORD record
ord-282c477e68bc406bac728496e306fa18
Source dataset
uspto-grants-2012_09
Patent number
US08273766B2

Reaction notes

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