HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 2-(2-Bromo-4-chlorophenoxy)acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | tert-Butyl (2-bromo-4-chlorophenoxy)acetate | HCID 49766393 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-(2-Bromo-4-chlorophenoxy)acetic acid | HCID 730302 | 99.9% |
Reaction Steps
A cooled (0° C.) solution of tert-butyl(2-bromo-4-chlorophenoxy)acetate (1.00 g; 3.11 mmol) in DCM (22 mL) was treated with trifluoroacetic acid (2.38 mL; 31.1 mmol). The reaction mixture was stirred at room temperature for 5 hours, the solvents were removed under vacuum to give the title compound (825 mg, quant.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08273769B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-b041b973705d4ae0b92a32e953777cbd |
| Source note | uspto-grants-2012_09 |