HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Bromo-4-fluorobenzonitrile → Tert-butyl{4-chloro-2-[(5-cyano-2-fluorophenyl)ethynyl]phenoxy}acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Bromo-4-fluorobenzonitrile | HCID 123579 | — |
| Reactant | Tert-butyl(4-chloro-2-ethynylphenoxy)acetate | HCID 56594381 | — |
| Product | Tert-butyl{4-chloro-2-[(5-cyano-2-fluorophenyl)ethynyl]phenoxy}acetate | HCID 58521989 | — |
Reaction Steps
Following the general method as outlined in Intermediate 19, starting from tert-butyl(4-chloro-2-ethynylphenoxy)acetate (Intermediate 3) and 3-bromo-4-fluorobenzonitrile (ABCR), the title compound was obtained as a beige solid after purification by flash column chromatography (silica), eluting with cyclohexane containing increasing amounts of EtOAc
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08273769B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-433e1ee34cc843729087b0b27f6e385e |
| Source note | uspto-grants-2012_09 |