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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2390124Generated: October 25, 2026

3-Bromo-2-methylpyridine → Tert-butyl{4-chloro-2-[(2-methylpyridin-3-yl)ethynyl]phenoxy}acetate

https://huagongshe.com/reaction/2390124

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-Bromo-2-methylpyridineHCID 1201003—
ReactantTert-butyl(4-chloro-2-ethynylphenoxy)acetateHCID 56594381—
ProductTert-butyl{4-chloro-2-[(2-methylpyridin-3-yl)ethynyl]phenoxy}acetateHCID 58521928—

Reaction Steps

Following the general method as outlined in Intermediate 19, starting from tert-butyl(4-chloro-2-ethynylphenoxy)acetate (Intermediate 3) and 3-bromo-2-methylpyridine (Synchem-OHG), the title compound was obtained as a yellow sticky solid after purification by preparative HPLC.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08273769B2
Source datasetuspto-grants-2012_09
ORD IDord-ccbd8eec367c44b3b021eaff2794922d
Source noteuspto-grants-2012_09