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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 2390127생성일: 2026년 10월 25일

3-Bromo-2-fluorobenzyl Alcohol → Tert-butyl(4-chloro-2-{[2-fluoro-3-(hydroxymethyl)phenyl]ethynyl}phenoxy)acetate

https://huagongshe.com/reaction/2390127

반응식

참여 물질

역할이름HCID투입량
반응물3-Bromo-2-fluorobenzyl AlcoholHCID 26985646—
반응물Tert-butyl(4-chloro-2-ethynylphenoxy)acetateHCID 56594381—
생성물Tert-butyl(4-chloro-2-{[2-fluoro-3-(hydroxymethyl)phenyl]ethynyl}phenoxy)acetateHCID 58521942—

반응 단계

Following the general method as outlined in Intermediate 19, starting from tert-butyl(4-chloro-2-ethynylphenoxy)acetate (Intermediate 3) and (3-bromo-2-fluorophenyl)methanol (Intermediate 11), the title compound was obtained as a dark brown sticky solid after purification by flash column chromatography (silica), eluting with cyclohexane containing increasing amounts of EtOAc.

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US08273769B2
출처 데이터셋uspto-grants-2012_09
ORD IDord-34df86b5f5684d9aac60e86be550e07e
출처 메모uspto-grants-2012_09