HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromo-1-fluoro-4-(methoxymethyl)benzene → HCID 58521849, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromo-1-fluoro-4-(methoxymethyl)benzene | HCID 2769416 | — |
| Reactant | Tert-butyl(4-chloro-2-ethynylphenoxy)acetate | HCID 56594381 | — |
| Product | HCID 58521849 | HCID 58521849 | — |
Reaction Steps
Following the general method as outlined in Intermediate 19, starting from tert-butyl(4-chloro-2-ethynylphenoxy)acetate (Intermediate 3) and 2-bromo-1-fluoro-4-(methoxymethyl)benzene (Intermediate 15), the title compound was obtained as a dark yellow sticky solid after purification by flash column chromatography (silica), eluting with cyclohexane containing increasing amounts of EtOAc.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08273769B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-b5fbd2dec8b24e63ad502f0db42e99a8 |
| Source note | uspto-grants-2012_09 |