tert-Butyl bromoacetate → HCID 58521988, compound

HRID 2390134Notes

Reaction equation

HRID 2390134 reaction equation
[C:1]([O:5][C:6](=[O:17])[CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12](Cl)=[CH:11][C:10]=1[Br:16])([CH3:4])([CH3:3])[CH3:2].BrC1C=CC([F:25])=CC=1O.BrCC(OC(C)(C)C)=O>>[C:1]([O:5][C:6](=[O:17])[CH2:7][O:8][C:9]1[CH:14]=[C:13]([F:25])[CH:12]=[CH:11][C:10]=1[Br:16])([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 3

HCID 79177tert-Butyl bromoacetateHCID 27246002-Bromo-5-fluorophenolHCID 49766393tert-Butyl (2-bromo-4-chlorophenoxy)acetate

Product 1

HCID 58521988HCID 58521988, compoundYield 95%

Procedure

Following the general method as outlined in Intermediate 1, starting from 2-bromo-5-fluorophenol and tert-butyl bromoacetate (Aldrich), the title compound was obtained as a white solid in 95% yield.

Sources & evidence

ORD record
ord-a5f2f63e362e4227afc5feffb41cfafd
Source dataset
uspto-grants-2012_09
Patent number
US08273769B2

Reaction notes

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