Tert-butyl(4-chloro-2-ethynylphenoxy)acetate → 2-Ethynyl-1-methyl-4-(propylsulfonyl) benzene

HRID 2390139Notes

Reaction equation

HRID 2390139 reaction equation
C(OC(=O)COC1C=CC(Cl)=CC=1C#C)(C)(C)C.C[Si](C)(C)[C:21]#[C:22][C:23]1[CH:28]=[C:27]([S:29]([CH2:32][CH2:33][CH3:34])(=[O:31])=[O:30])[CH:26]=[CH:25][C:24]=1[CH3:35]>>[C:22]([C:23]1[CH:28]=[C:27]([S:29]([CH2:32][CH2:33][CH3:34])(=[O:30])=[O:31])[CH:26]=[CH:25][C:24]=1[CH3:35])#[CH:21]

Participants

3

Reactant 2

HCID 56594381Tert-butyl(4-chloro-2-ethynylphenoxy)acetateHCID 585220372-Trimethylsilylethynyl-1-methyl-4-(propylsulfonyl)benzene2×

Product 1

HCID 585220332-Ethynyl-1-methyl-4-(propylsulfonyl) benzene

Procedure

Following the general method as outlined in Intermediate 3, starting from 2-trimethylsilylethynyl-1-methyl-4-(propylsulfonyl)benzene (Intermediate 39), the title compound was obtained as a brown liquid after purification by column chromatography (silica) eluting with petroleum ether and ethyl acetate.

Sources & evidence

ORD record
ord-8c73ee39ac60483981262804de2a8ae4
Source dataset
uspto-grants-2012_09
Patent number
US08273769B2

Reaction notes

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