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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2390141Generated: October 29, 2026

1-(2-Trimethylsilyl-1-ethynyl)-3-(propylsulfonyl)benzene → 1-Ethynyl-3-(propylsulfonyl)benzene

https://huagongshe.com/reaction/2390141

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(2-Trimethylsilyl-1-ethynyl)-3-(propylsulfonyl)benzeneHCID 56594266—
ReactantTert-butyl(4-chloro-2-ethynylphenoxy)acetateHCID 56594381—
Product1-Ethynyl-3-(propylsulfonyl)benzeneHCID 5659426770%

Reaction Steps

Following the general method as outlined in Intermediate 3, starting from 1-(2-trimethylsilyl-1-ethynyl)-3-(propylsulfonyl)benzene (Intermediate 41), the title compound was obtained as a brown liquid in 70% yield after purification by column chromatography (silica) eluting with petroleum ether and ethyl acetate.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08273769B2
Source datasetuspto-grants-2012_09
ORD IDord-380274e14d2f4bf48e1829b06270b25c
Source noteuspto-grants-2012_09