HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Bromo-4-methylpyridine → Tert-butyl{4-cyano-2-[(4-methylpyridin-3-yl)ethynyl]phenoxy}acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Bromo-4-methylpyridine | HCID 817630 | — |
| Reactant | Tert-butyl(4-cyano-2-ethynylphenoxy)acetate | HCID 58522073 | — |
| Product | Tert-butyl{4-cyano-2-[(4-methylpyridin-3-yl)ethynyl]phenoxy}acetate | HCID 58522020 | — |
Reaction Steps
Following the general method as outlined in Intermediate 20, starting from tert-butyl(4-cyano-2-ethynylphenoxy)acetate (Intermediate 46) and 3-bromo-4-methylpyridine (53), the title compound was obtained as a dark orange sticky solid after purification by flash column chromatography, eluting with cyclohexane containing increasing amounts of EtOAc.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08273769B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-c8578c97095c40b098d31e227974835b |
| Source note | uspto-grants-2012_09 |