2-Iodophenol → HCID 58521990, compound

HRID 2390152Notes

Reaction equation

[C:1]([O:5][C:6](=[O:17])[CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12](Cl)=[CH:11][C:10]=1Br)([CH3:4])([CH3:3])[CH3:2].[I:18]C1C=CC=CC=1O.BrCC(OC(C)(C)C)=O>>[C:1]([O:5][C:6](=[O:17])[CH2:7][O:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[I:18])([CH3:4])([CH3:3])[CH3:2]

Participants

Reactant 3

HCID 107842-Iodophenol

HCID 79177tert-Butyl bromoacetate

HCID 49766393tert-Butyl (2-bromo-4-chlorophenoxy)acetate

Product 1

HCID 58521990HCID 58521990, compound

Procedure

Following the general method as outlined in Intermediate 1, starting from 2-iodophenol and tert-butyl bromoacetate (Aldrich), the title compound was obtained as a yellow liquid in quantitative yield.

Sources & evidence

ORD record: ord-e0dd046e00ca41a990cdc7531687990c
Source dataset: uspto-grants-2012_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08273769B2

Reaction notes

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