1-Fluoro-4-methanesulfonyl-2-nitrobenzene → 2-Fluoro-5-(methylsulfonyl)aniline

Participants

Reaction Steps

A mixture of 4-fluoro-3-nitrophenyl methyl sulfone (ABCR; 1.50 g; 6.84 mmol) and 10% Pd/C (100 mg) in MeOH (30 ml) was placed in a PARR reactor and treated with a pressure of 15 atm of hydrogen for 2 hours. The reaction mixture was filtered through Celite and the filtrate was concentrated to dryness affording the title compound (1.04 g, 80%).

Provenance & Evidence