1-Ethynyl-3-(propylsulfonyl)benzene → Tert-butyl[2-{[3-(propylsulfonyl)phenyl]ethynyl}-4-(trifluoromethyl)phenoxy]acetate

Participants

Role	Name	HCID	Charge
Reactant	1-Ethynyl-3-(propylsulfonyl)benzene	HCID 56594267	—
Reactant	Tert-butyl (2-bromo-4-trifluoromethylphenoxy)acetate	HCID 58297405	—
Product	Tert-butyl[2-{[3-(propylsulfonyl)phenyl]ethynyl}-4-(trifluoromethyl)phenoxy]acetate	HCID 58522052	—

Reaction Steps

Following the general method as outlined in Intermediate 20, starting from tert-butyl[2-bromo-4-(trifluoromethyl)phenoxy]acetate (Intermediate 35) and 1-ethynyl-3-(propane-1-sulfonyl)-benzene (Intermediate 42), the title compound was obtained as a colorless oil after purification by flash column chromatography (silica), eluting with cyclohexane containing increasing amounts of EtOAc

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08273769B2
Source dataset	uspto-grants-2012_09
ORD ID	ord-d901a368a4b5499d97042654fa91fe7e
Source note	uspto-grants-2012_09