2-Iodo-4-(methylsulfonyl)-1-propylbenzene → Tert-butyl(4-cyano-2-{[5-(methylsulfonyl)-2-propylphenyl]ethynyl}phenoxy)acetate

Participants

Role	Name	HCID	Charge
Reactant	2-Iodo-4-(methylsulfonyl)-1-propylbenzene	HCID 58522003	—
Reactant	Tert-butyl(4-cyano-2-ethynylphenoxy)acetate	HCID 58522073	—
Product	Tert-butyl(4-cyano-2-{[5-(methylsulfonyl)-2-propylphenyl]ethynyl}phenoxy)acetate	HCID 58522038	—

Reaction Steps

Following the general method as outlined in Intermediate 20, starting from (4-cyano-2-ethynyl-phenoxy)-acetic acid tert-butyl ester (Intermediate 46) and 2-iodo-4-(methylsulfonyl)-1-propylbenzene (Intermediate 62), the title compound was obtained after purification by flash column chromatography (silica), eluting with cyclohexane containing increasing amounts of EtOAc.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08273769B2
Source dataset	uspto-grants-2012_09
ORD ID	ord-555b50713def4b41a59ca0aa31161a58
Source note	uspto-grants-2012_09