Tert-butyl(4-cyano-2-ethynylphenoxy)acetate → Tert-butyl(2-{[2-chloro-5-(methylsulfonyl)phenyl]ethynyl}-4-cyanophenoxy)acetate

Participants

Reaction Steps

Following the general method as outlined in Intermediate 79, starting from (4-cyano-2-ethynyl-phenoxy)-acetic acid tert-butyl ester (Intermediate 46) and 1-chloro-2-iodo-4-(methylsulfonyl)benzene (Intermediate 74), the title compound was obtained as a yellow solid in 74% yield after purification by flash column chromatography (silica), eluting with cyclohexane containing increasing amounts of EtOAc.

Provenance & Evidence