Tert-butyl{4-chloro-2-[(trimethylsilyl)ethynyl]phenoxy}acetate → Tert-butyl {[2-(trimethylsilyl-1-ethynyl)-6-methylpyridin-3-yl]oxy}acetate

Participants

Role	Name	HCID	Charge
Reactant	Tert-butyl{4-chloro-2-[(trimethylsilyl)ethynyl]phenoxy}acetate	HCID 56594380	—
Reactant	Tert-butyl 2-[(2-bromo-6-methyl-3-pyridinyl)oxy]acetate	HCID 58522063	—
Product	Tert-butyl {[2-(trimethylsilyl-1-ethynyl)-6-methylpyridin-3-yl]oxy}acetate	HCID 58521867	—

Reaction Steps

Following the general method as outlined in Intermediate 2, starting from tert-butyl[(2-bromo-6-methylpyridin-3-yl)oxy]acetate (Intermediate 84), the title compound was obtained as a brown oil after purification by flash column chromatography (silica), eluting with petroleum ether and ethyl acetate (98:2).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08273769B2
Source dataset	uspto-grants-2012_09
ORD ID	ord-2658e31aefe24acba0b6035f4b214b5d
Source note	uspto-grants-2012_09