Tert-butyl{4-chloro-2-[(trimethylsilyl)ethynyl]phenoxy}acetate → tert-Butyl [(2-ethynyl-6-methylpyridin-3-yl)oxy]acetate

HRID 2390172ノート

反応式

HRID 2390172 の反応式
C(OC(=O)COC1C=CC(Cl)=CC=1C#C[Si](C)(C)C)(C)(C)C.[C:23]([O:27][C:28](=[O:44])[CH2:29][O:30][C:31]1[C:32]([C:38]#[C:39][Si](C)(C)C)=[N:33][C:34]([CH3:37])=[CH:35][CH:36]=1)([CH3:26])([CH3:25])[CH3:24]>>[C:38]([C:32]1[C:31]([O:30][CH2:29][C:28]([O:27][C:23]([CH3:25])([CH3:24])[CH3:26])=[O:44])=[CH:36][CH:35]=[C:34]([CH3:37])[N:33]=1)#[CH:39]

参加物

3

反応物 2

HCID 56594380Tert-butyl{4-chloro-2-[(trimethylsilyl)ethynyl]phenoxy}acetateHCID 58521867Tert-butyl {[2-(trimethylsilyl-1-ethynyl)-6-methylpyridin-3-yl]oxy}acetate2 回

生成物 1

HCID 58521986tert-Butyl [(2-ethynyl-6-methylpyridin-3-yl)oxy]acetate収率 91%

実験手順

Following the general method as outlined in Intermediate 2, starting from tert-butyl{[2-(trimethylsilyl-1-ethynyl)-6-methylpyridin-3-yl]oxy}acetate (Intermediate 85), the title compound was obtained in 91% yield as a brown oil after purification by flash column chromatography (silica), eluting with petroleum ether and ethyl acetate (98:2).

出典と根拠

ORDレコード
ord-e9e01ea57374490a9d756701052d6095
出典データセット
uspto-grants-2012_09
特許番号
US08273769B2

反応ノート

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