1-Bromo-3-(propylsulfonyl)benzene → Tert-butyl[(6-methyl-2-{[3-(propylsulfonyl)phenyl]ethynyl}pyridin-3-yl)oxy]acetate

Participants

Reaction Steps

Following the general method as outlined in Intermediate 20, starting from (2-ethynyl-6-methyl-pyridin-3-yloxy)-acetic acid tert-butyl ester (Intermediate 86) and 1-bromo-3-(propane-1-sulfonyl)-benzene (Intermediate 5), the title compound was obtained as a yellow sticky solid after purification by flash column chromatography (silica), eluting with cyclohexane containing increasing amounts of EtOAc.

Provenance & Evidence