HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromo-5-methylsulfonylnitrobenzene → 1-Isopropenyl-4-(methylsulfonyl)-2-nitrobenzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromo-5-methylsulfonylnitrobenzene | HCID 2060366 | — |
| Reactant | 4,4,5,5-Tetramethyl-2-(prop-1-en-2-yl)-1,3,2-dioxaborolane | HCID 10997426 | — |
| Reactant | 4-(methylsulfonyl)-2-nitro-1-[(1E)-prop-1-en-1-yl]benzene | HCID 58521984 | — |
| Product | 1-Isopropenyl-4-(methylsulfonyl)-2-nitrobenzene | HCID 58521898 | — |
Reaction Steps
Following the general method as outlined in Intermediate 59, starting from 2-bromo-5-methylsulfonylnitrobenzene and isopropenylboronic acid pinacol ester, the title compound was obtained as a brown oil in quantitative yield after purification by flash column chromatography (silica), eluting with cyclohexane containing increasing amounts of EtOAc.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08273769B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-10c7eb26203042649ac57ecb2fead673 |
| Source note | uspto-grants-2012_09 |