HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Chloro-2-iodophenol → Tert-butyl(3-chloro-2-iodophenoxy)acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Chloro-2-iodophenol | HCID 12175702 | — |
| Reactant | tert-Butyl (2-bromo-4-chlorophenoxy)acetate | HCID 49766393 | — |
| Product | Tert-butyl(3-chloro-2-iodophenoxy)acetate | HCID 16741488 | 86% |
Reaction Steps
Following the general method as outlined in Intermediate 1, starting from 3-chloro-2-iodophenol (prepared as described in J. Org. Chem., 2005, 70, 6548-6551), the title compound was obtained as a white solid in 86% yield after purification by flash column chromatography (silica), eluting with cyclohexane containing increasing amounts of EtOAc.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08273769B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-3d0ecf57304b45aa95cd44b81b637080 |
| Source note | uspto-grants-2012_09 |