HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(3-Bromo-4-methylbenzene-1-sulfonyl)morpholine → HCID 58521897, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(3-Bromo-4-methylbenzene-1-sulfonyl)morpholine | HCID 7213309 | — |
| Reactant | Tert-butyl(4-chloro-2-ethynylphenoxy)acetate | HCID 56594381 | — |
| Product | HCID 58521897 | HCID 58521897 | 81% |
Reaction Steps
Following the general method as outlined in Intermediate 20, starting from (4-chloro-2-ethynyl-phenoxy)-acetic acid tert-butyl ester (Intermediate 3) and 1-(3-bromo-4-methylphenylsulfonyl)morpholine (Combiblocks), the title compound was obtained as a yellow sticky solid in 81% yield after purification by flash column chromatography (silica), eluting with cyclohexane containing increasing amounts of EtOAc.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08273769B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-52e7a04480a64a30b2a9efce9728535e |
| Source note | uspto-grants-2012_09 |