Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2390192Generated: October 26, 2026

Tert-butyl{4-chloro-2-[(trimethylsilyl)ethynyl]phenoxy}acetate → {[2-Fluoro-5-(propylsulfonyl)phenyl]ethynyl}trimethyl silane

https://huagongshe.com/reaction/2390192

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTert-butyl{4-chloro-2-[(trimethylsilyl)ethynyl]phenoxy}acetateHCID 56594380—
Reactant2-Bromo-1-fluoro-4-(propylsulfonyl)benzeneHCID 58522071—
Product{[2-Fluoro-5-(propylsulfonyl)phenyl]ethynyl}trimethyl silaneHCID 5852187497%

Reaction Steps

Following the general method as outlined in Intermediate 2, starting from 2-bromo-1-fluoro-4-(propylsulfonyl)benzene (Intermediate 106) and trimethylsilylacetilene, the title compound was obtained as a brown liquid in 97% yield.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08273769B2
Source datasetuspto-grants-2012_09
ORD IDord-6c218338e49341afb37240d8cb66ae74
Source noteuspto-grants-2012_09