Tert-butyl(4-chloro-2-ethynylphenoxy)acetate → 2-Ethynyl-1-fluoro-4-(propylsulfonyl)benzene

Participants

Role	Name	HCID	Charge
Reactant	Tert-butyl(4-chloro-2-ethynylphenoxy)acetate	HCID 56594381	—
Reactant	{[2-Fluoro-5-(propylsulfonyl)phenyl]ethynyl}trimethyl silane	HCID 58521874	—
Product	2-Ethynyl-1-fluoro-4-(propylsulfonyl)benzene	HCID 58521935	—

Reaction Steps

Following the general method as outlined in Intermediate 3, starting from {[2-Fluoro-5-(propylsulfonyl)phenyl]ethynyl}trimethyl silane (Intermediate 107), the title compound was obtained as a brown liquid after purification by column chromatography (silica) eluting with petroleum ether and ethyl acetate.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08273769B2
Source dataset	uspto-grants-2012_09
ORD ID	ord-7f6eecfe3e084793923a6d5c2fa75df2
Source note	uspto-grants-2012_09