HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Bromo-4-(methylsulphonyl)benzene → 2-Methyl-5-(phenylsulfonyl)aniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Bromo-4-(methylsulphonyl)benzene | HCID 77014 | — |
| Reactant | 1-Methyl-2-nitro-4-(phenylsulfonyl)benzene | HCID 56593976 | — |
| Reactant | 5-(Methylsulfonyl)-2-propylaniline | HCID 58522006 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 2-Methyl-5-(phenylsulfonyl)aniline | HCID 21555469 | 94% |
Reaction Steps
Following the general method as outlined in Intermediate 61 using MeOH and EtOAc as solvents, starting from 1-methyl-2-nitro-4-(phenylsulfonyl)benzene (Intermediate 112) and 4-bromophenyl methyl sulfone, the title compound was obtained as a beige solid in 94% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08273769B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-ef3929842697450580ce7764d3b6a8f4 |
| Source note | uspto-grants-2012_09 |