HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Iodo-1-methyl-4-(phenylsulfonyl)benzene → Tert-butyl(4-cyano-2-{[2-methyl-5-(phenylsulfonyl)phenyl]ethynyl}phenoxy)acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Iodo-1-methyl-4-(phenylsulfonyl)benzene | HCID 56593977 | — |
| Reactant | Tert-butyl(4-cyano-2-ethynylphenoxy)acetate | HCID 58522073 | — |
| Product | Tert-butyl(4-cyano-2-{[2-methyl-5-(phenylsulfonyl)phenyl]ethynyl}phenoxy)acetate | HCID 131729962 | 89% |
Reaction Steps
Following the general method as outlined in Intermediate 79, starting from (4-cyano-2-ethynyl-phenoxy)-acetic acid tert-butyl ester (Intermediate 46) and 2-iodo-1-methyl-4-(phenylsulfonyl)benzene (Intermediate 114), the title compound was obtained as a brown sticky solid in 89% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08273769B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-ed2f5d86dcad4e0cb56d2882301c3fe5 |
| Source note | uspto-grants-2012_09 |