1-Ethynyl-3-(propylsulfonyl)benzene → Tert-butyl(4-fluoro-2-{[3-(propylsulfonyl)phenyl]ethynyl}phenoxy)acetate

Participants

Role	Name	HCID	Charge
Reactant	1-Ethynyl-3-(propylsulfonyl)benzene	HCID 56594267	—
Reactant	{[2-Fluoro-5-(propylsulfonyl)phenyl]ethynyl}trimethyl silane	HCID 58521874	—
Reactant	Tert-butyl (2-bromo-4-fluorophenoxy)acetate	HCID 59642165	—
Product	Tert-butyl(4-fluoro-2-{[3-(propylsulfonyl)phenyl]ethynyl}phenoxy)acetate	HCID 58521846	—

Reaction Steps

Following the general method as outlined in Intermediate 107, starting from tert-butyl(2-bromo-4-fluorophenoxy)acetate (Intermediate 119) and 1-ethynyl-3-(propane-1-sulfonyl)-benzene (Intermediate 42), the title compound was obtained as a yellow sticky solid after purification by flash column chromatography (silica), eluting with cyclohexane containing increasing amounts of EtOAc.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08273769B2
Source dataset	uspto-grants-2012_09
ORD ID	ord-3877c77a4b18407f9b281d6f14131e62
Source note	uspto-grants-2012_09