Tert-butyl(4-chloro-2-ethynylphenoxy)acetate → Tert-butyl(4-chloro-2-{[2-chloro-5-(propylsulfonyl)phenyl]ethynyl}phenoxy)acetate

Participants

Role	Name	HCID	Charge
Reactant	Tert-butyl(4-chloro-2-ethynylphenoxy)acetate	HCID 56594381	—
Reactant	{[2-Fluoro-5-(propylsulfonyl)phenyl]ethynyl}trimethyl silane	HCID 58521874	—
Reactant	2-Bromo-1-chloro-4-(propylsulfonyl)benzene	HCID 58522088	—
Product	Tert-butyl(4-chloro-2-{[2-chloro-5-(propylsulfonyl)phenyl]ethynyl}phenoxy)acetate	HCID 58522000	—

Reaction Steps

Following the general method as outlined in Intermediate 107, starting from (4-chloro-2-ethynyl-phenoxy)-acetic acid tert-butyl ester (Intermediate 3) and 2-bromo-1-chloro-4-(propylsulfonyl)benzene (Intermediate 126), the title compound was obtained as a colorless oil after purification by flash column chromatography (silica), eluting with cyclohexane containing increasing amounts of EtOAc.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08273769B2
Source dataset	uspto-grants-2012_09
ORD ID	ord-0f04dc644f8544c08f8c95ec0970bebe
Source note	uspto-grants-2012_09