1-Fluoro-4-(propane-2-sulfonyl)benzene → 2-Bromo-1-fluoro-4-(isopropylsulfonyl)benzene

HRID 2390209Notes

Reaction equation

HRID 2390209 reaction equation
[Br:1][C:2]1[CH:7]=[C:6]([S:8]([CH2:11][CH2:12]C)(=[O:10])=[O:9])[CH:5]=[CH:4][C:3]=1[F:14].F[C:16]1C=CC(S(C(C)C)(=O)=O)=CC=1>>[Br:1][C:2]1[CH:7]=[C:6]([S:8]([CH:11]([CH3:12])[CH3:16])(=[O:9])=[O:10])[CH:5]=[CH:4][C:3]=1[F:14]

Participants

3

Reactant 2

HCID 142895261-Fluoro-4-(propane-2-sulfonyl)benzeneHCID 585220712-Bromo-1-fluoro-4-(propylsulfonyl)benzene

Product 1

HCID 585219702-Bromo-1-fluoro-4-(isopropylsulfonyl)benzeneYield 89%

Procedure

Following the general method as outlined in Intermediate 106, starting from 1-fluoro-4-(isopropylsulfonyl)benzene, the title compound was obtained as an oil which solidifies upon standing in 89% yield.

Sources & evidence

ORD record
ord-e29e778785084dd9ab0264e089b3e9ce
Source dataset
uspto-grants-2012_09
Patent number
US08273769B2

Reaction notes

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