HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 45156879, compound → HCID 58521840, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 45156879 | HCID 45156879 | — |
| Reactant | Tert-butyl(4-chloro-2-ethynylphenoxy)acetate | HCID 56594381 | — |
| Reactant | {[2-Fluoro-5-(propylsulfonyl)phenyl]ethynyl}trimethyl silane | HCID 58521874 | — |
| Product | HCID 58521840 | HCID 58521840 | — |
Reaction Steps
Following the general method as outlined in Intermediate 107, starting from (4-chloro-2-ethynyl-phenoxy)-acetic acid tert-butyl ester (Intermediate 3) and 2-bromo-1-chloro-4-(isopropylsulfonyl)benzene (Intermediate 129), the title compound was obtained as a white solid after purification by flash column chromatography (silica), eluting with cyclohexane containing increasing amounts of EtOAc.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08273769B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-20567942919045e1b52f5c262cfd5094 |
| Source note | uspto-grants-2012_09 |