HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tert-butyl(4-chloro-2-ethynylphenoxy)acetate → HCID 58521966, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tert-butyl(4-chloro-2-ethynylphenoxy)acetate | HCID 56594381 | — |
| Reactant | {[2-Fluoro-5-(propylsulfonyl)phenyl]ethynyl}trimethyl silane | HCID 58521874 | — |
| Reactant | 2-Bromo-4-(ethylsulfonyl)-1-fluorobenzene | HCID 58521975 | — |
| Product | HCID 58521966 | HCID 58521966 | 86% |
Reaction Steps
Following the general method as outlined in Intermediate 107, starting from (4-chloro-2-ethynyl-phenoxy)-acetic acid tert-butyl ester (Intermediate 3) and 2-bromo-4-ethanesulfonyl-1-fluoro-benzene (Intermediate 130), the title compound was obtained as a colorless oil in 86% yield after purification by flash column chromatography (silica), eluting with cyclohexane containing increasing amounts of EtOAc.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08273769B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-0c3c33bebb064aaabd8394b6d4f9b48a |
| Source note | uspto-grants-2012_09 |