HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tert-butyl(4-chloro-2-ethynylphenoxy)acetate → HCID 58521868, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tert-butyl(4-chloro-2-ethynylphenoxy)acetate | HCID 56594381 | — |
| Reactant | {[2-Fluoro-5-(propylsulfonyl)phenyl]ethynyl}trimethyl silane | HCID 58521874 | — |
| Reactant | HCID 58521918 | HCID 58521918 | — |
| Product | HCID 58521868 | HCID 58521868 | 80% |
Reaction Steps
Following the general method as outlined in Intermediate 107, starting from (4-chloro-2-ethynyl-phenoxy)-acetic acid tert-butyl ester (Intermediate 3) and 2-Bromo-1-fluoro-4-(2-methoxy-ethanesulfonyl)-benzene (Intermediate 132), the title compound was obtained as a colorless oil in 80% yield after purification by flash column chromatography (silica), eluting with cyclohexane containing increasing amounts of EtOAc.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08273769B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-a9cc2d54f64b40db8390396904d78f21 |
| Source note | uspto-grants-2012_09 |