反应详情

A solution of 4-fluoro-N,N-dimethylbenzenesulfonamide (1.80 g; 8.86 mmol) in conc. sulfuric acid (7 ml; 130 mmol) was treated with N-bromosuccinimide (1 730 mg; 9.74 mmol) and stirred at RT for 3 h. The reaction mixture was carefully poured on crushed ice, extracted with AcOEt and the organic phase was washed with a 0.1 N solution of NaOH in water twice, then with brine twice. The organic phase was dried on MgSO4, filtered and concentrated under reduced pressure to give the title compound as a white solid (2.04 g, 82%).

1. additionThe reaction mixture was carefully poured
2. customon crushed ice
3. extractionextracted with AcOEt
4. washthe organic phase was washed with a 0.1 N solution of NaOH in water twice
5. customThe organic phase was dried on MgSO4
6. filtrationfiltered
7. concentrationconcentrated under reduced pressure