HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(3-Bromo-4-methylbenzene-1-sulfonyl)piperidine → HCID 58521859, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(3-Bromo-4-methylbenzene-1-sulfonyl)piperidine | HCID 7213306 | — |
| Reactant | Tert-butyl(4-chloro-2-ethynylphenoxy)acetate | HCID 56594381 | — |
| Product | HCID 58521859 | HCID 58521859 | — |
Reaction Steps
Following the general method as outlined in Intermediate 20, starting from (4-chloro-2-ethynyl-phenoxy)-acetic acid tert-butyl ester (Intermediate 3) and 1-[(3-bromo-4-methylphenyl)sulfonyl]piperidine (Intermediate 139), the title compound was obtained as a yellow solid after purification by flash column chromatography (silica), eluting with cyclohexane containing increasing amounts of EtOAc.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08273769B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-e76a672feeb04a039490e872cd8430db |
| Source note | uspto-grants-2012_09 |