Tert-butyl(4-chloro-2-ethynylphenoxy)acetate → HCID 58522025, compound

Participants

Reaction Steps

Following the general method as outlined in Intermediate 20, starting from (4-chloro-2-ethynyl-phenoxy)-acetic acid tert-butyl ester (Intermediate 3) and 3-bromo-N-(2-dimethylamino-ethyl)-4,N-dimethyl-benzenesulfonamide (Intermediate 154), the title compound was obtained as a yellow sticky solid after purification by flash column chromatography (silica), eluting with cyclohexane containing increasing amounts of EtOAc.

Provenance & Evidence