Tert-butyl[(3-bromo-5-chloropyridin-2-yl)oxy]acetate → Tert-butyl[(5-chloro-3-{[2-fluoro-5-(propylsulfonyl)phenyl]ethynyl}pyridin-2-yl)oxy]acetate

Participants

Reaction Steps

Following the general method as outlined in Intermediate 182, starting from tert-butyl[(3-bromo-5-chloropyridin-2-yl)oxy]acetate (Intermediate 183) and 2-ethynyl-1-fluoro-4-(propane-1-sulfonyl)-benzene (Intermediate 109), the title compound was obtained as a yellow sticky solid after purification by flash column chromatography (silica), eluting with cyclohexane containing increasing amounts of EtOAc.

Provenance & Evidence