Hydrochloric Acid → HCID 58521933, compound

Participants

Reaction Steps

Diethyl {3-bromo-5-[(dimethylamino)sulfonyl]pyridin-2-yl}malonate (222 mg; 0.52 mmol) was treated with a 5 N solution of HCl in water (11 ml) and the resulting solution was refluxed for 6 h. The solvent was removed under reduced pressure, and the solid residue was carefully quenched with a saturated Na2CO3 solution in water. The resulting suspension was extracted with AcOEt. The organic phase was washed with brine, dried on MgSO4, filtered and concentrated under reduced pressure to give the title compound as a white solid (125 mg; 86% yield).

Provenance & Evidence