N-bromobutanimide → HCID 58521981, compound

Participants

Reaction Steps

A suspension of 1-iodo-2-(methylsulfonyl)benzene (Intermediate 201; 1.45 g; 5.14 mmol) in conc. H2SO4 (4 mL) was treated with N-bromosuccinimide (1.01 g; 5.65 mmol) and the resulting mixture was stirred for 4 h. The reaction mixture was carefully poured on crushed ice and extracted with EtOAc. The organic phase was washed twice with NaOH 0.1 N and brine, dried over MgSO4, filtered and concentrated to dryness affording the title compound as a white solid (1.6 g, 86%).

Provenance & Evidence