(3-Chlorophenyl)boronic acid → HCID 58521831, compound

HRID 2390269Notes

Reaction equation

HRID 2390269 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[C:4]([S:14]([CH3:17])(=[O:16])=[O:15])[CH:3]=1.BrC1C=CC(I)=C(S(C)(=O)=O)C=1.[Cl:30]C1C=C(B(O)O)C=CC=1>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([Cl:30])[CH:9]=2)=[C:4]([S:14]([CH3:17])(=[O:16])=[O:15])[CH:3]=1

Participants

4

Reactant 3

HCID 2734323(3-Chlorophenyl)boronic acidHCID 58521957HCID 58521957, compoundHCID 58521981HCID 58521981, compound2×

Product 1

HCID 58521831HCID 58521831, compound

Procedure

Following the general method as outlined in Intermediate 203, starting from 4-bromo-1-iodo-2-(methylsulfonyl)benzene (Intermediate 202) and 3-chlorophenylboronic acid, the title compound was obtained as a brown sticky solid after purification by flash column chromatography (silica), eluting with cyclohexane containing increasing amounts of EtOAc.

Sources & evidence

ORD record
ord-d560b6e9f26043809a85b41ae739a115
Source dataset
uspto-grants-2012_09
Patent number
US08273769B2

Reaction notes

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