HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromo-1-methyl-4-(propylsulfinyl)benzene → Methyl (4-chloro-2-{[2-methyl-5-(propylsulfinyl)phenyl]ethynyl}phenoxy)acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromo-1-methyl-4-(propylsulfinyl)benzene | HCID 56593978 | — |
| Reactant | {[2-Fluoro-5-(propylsulfonyl)phenyl]ethynyl}trimethyl silane | HCID 58521874 | — |
| Reactant | Methyl (4-chloro-2-ethynylphenoxy)acetate | HCID 58522019 | — |
| Product | Methyl (4-chloro-2-{[2-methyl-5-(propylsulfinyl)phenyl]ethynyl}phenoxy)acetate | HCID 56593979 | — |
Reaction Steps
Following the general method as outlined in Intermediate 107, starting from methyl (4-chloro-2-ethynylphenoxy)acetate (Intermediate 220) and 2-bromo-1-methyl-4-(propylsulfinyl)benzene (Intermediate 219), the title compound was obtained as a yellow oil after purification by flash column chromatography (silica), eluting with cyclohexane containing increasing amounts of EtOAc.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08273769B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-77ae0bb8a5f542079e1600e837e090e2 |
| Source note | uspto-grants-2012_09 |