HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetyl chloride → HCID 101043386, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetyl chloride | HCID 6367 | — |
| Reactant | HCID 58522032 | HCID 58522032 | — |
| Product | HCID 101043386 | HCID 101043386 | 91% |
Reaction Steps
Following the general method as outlined in Intermediate 223, starting from tert-butyl{2-[(4-aminophenyl)ethynyl]-4-chlorophenoxy}acetate (Intermediate 222) and acetyl chloride, the title compound was obtained in 91% yield after purification by flash column chromatography (silica), eluting with cyclohexane containing increasing amounts of EtOAc.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08273769B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-7807966062004000962325204681fc87 |
| Source note | uspto-grants-2012_09 |