HCID 58522008, compound → HCID 43168856, compound

HRID 2390282Notes

Reaction equation

HRID 2390282 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([CH2:11][CH2:12][CH3:13])(=[O:10])=[O:9])=[C:4]([N+:14]([O-])=O)[CH:3]=1.[H][H]>CO.[Pd]>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([CH2:11][CH2:12][CH3:13])(=[O:10])=[O:9])=[C:4]([CH:3]=1)[NH2:14]

Participants

5

Reactant 2

HCID 58522008HCID 58522008, compound2×HCID 178418361HCID 178418361, compound

Product 1

HCID 43168856HCID 43168856, compoundYield 94%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A solution of 4-methyl-2-nitro-1-(propylsulfonyl)benzene (Intermediate 227; 11 g, 45 mmol) in methanol (150 ml) was treated with Pd/C (1.1 g) and the reaction mixture was stirred under 3 Kg/cm2 pressure of hydrogen at RT for 5 h. The catalyst was filtered through celite and the solvent was removed under reduced pressure to afford the title compound (9 g, 94%) as pale yellow liquid.

Workup

  1. filtrationThe catalyst was filtered through celite
  2. customthe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-371dd81165b74473b976e26b74e9e612
Source dataset
uspto-grants-2012_09
Patent number
US08273769B2

Reaction notes

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