HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (4-Chloro-2-ethynylphenoxy)acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1,4-Dioxane | HCID 31275 | — |
| Reactant | Tert-butyl(4-chloro-2-ethynylphenoxy)acetate | HCID 56594381 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (4-Chloro-2-ethynylphenoxy)acetic acid | HCID 58522016 | — |
Reaction Steps
A solution of (4-chloro-2-ethynyl-phenoxy)-acetic acid tert-butyl ester (Intermediate 3; 500 mg; 1.87 mmol) in DCM (2.5 ml) was treated with a 4 N solution of HCl in dioxane (14 ml; 56 mmol) and stirred overnight. The solvents were removed under reduced pressure, to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08273769B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-fa87e976861643c7b2571efe937e24ef |
| Source note | uspto-grants-2012_09 |